The sulfidation behavior of zinc during microwave hydrothermal sulfidation of heavy metal-containing sludge.

The heavy metals present in the sludge can undergo a reaction with sulfur, leading to their conversion into metal sulfides through hydrothermal sulfidation. Sulfur ions, possessing a strong sulfidation capability, can operate within a wider pH range at elevated temperatures. The high temperature environment promotes the sulfidation process of zinc within heavy metal-laden sludge. Increasing the temperature of microwave hydrothermal sulfidation and extending the sulfidation duration for heavy metal-containing sludge can enhance the growth of crystal size in the artificially synthesized zinc sulfide. Zinc sulfide predominantly takes the form of ZnS, which facilitates the subsequent flotation recovery of zinc.

Targeted co-delivery of curcumin and erlotinib by MoS2 nanosheets for the combination of synergetic chemotherapy and photothermal therapy of lung cancer.

BACKGROUND: Curcumin (Cur), a bioactive component of Chinese traditional medicine, has demonstrated inhibitory properties against cancer cell proliferation while synergistically enhancing the anticancer efficacy of erlotinib (Er). However, the individual limitations of both drugs, including poor aqueous solubility, lack of targeting ability, short half-life, etc., and their distinct pharmacokinetic profiles mitigate or eliminate their combined antitumor potential. RESULTS: In this study, we developed a molybdenum disulfide (MoS2)-based delivery system, functionalized with polyethylene glycol (PEG) and biotin, and co-loaded with Cur and Er, to achieve efficient cancer therapy. The MoS2-PEG-Biotin-Cur/Er system effectively converted near-infrared (NIR) light into heat, thereby inducing direct photothermal ablation of cancer cells and promoting controlled release of Cur and Er. Biotin-mediated tumor targeting facilitated the selective accumulation of MoS2-PEG-Biotin-Cur/Er at the tumor site, thus enhancing the synergistic antitumor effects of Cur and Er. Remarkably, MoS2-PEG-Biotin-Cur/Er achieved the combination of synergistic chemotherapy and photothermal therapy (PTT) upon NIR irradiation, effectively suppressing lung cancer cell proliferation and inhabiting tumor growth in vivo. CONCLUSIONS: The as-synthesized MoS2-PEG-Biotin-Cur/Er, featuring high targeting ability, NIR light-responsive drug release, and the integration of synergistic chemotherapy and PTT, may provide a promising strategy for the treatment of lung cancer in clinical practice.

Application of inorganic selenium to reduce accumulation and toxicity of heavy metals (metalloids) in plants: The main mechanisms, concerns, and risks.

Anthropogenic activities such as mining, industrialization and subsequent emission of industrial waste, and agricultural practices have led to an increase in the accumulation of metal(loid)s in agricultural soils and crops, which threatens the health of people; the risk is more pronounced for individuals whose survival depends on food sources from several contaminated regions. Selenium (Se) is an element essential for the normal functioning of the human body and is a beneficial element for plants. Se deficiency in the diet is a common issue in many countries around the world, such as China and Egypt. >40 diseases are associated with Se deficiency. In practice, Se compounds have been applied through foliar sprays or via base application of fertilizers to increase Se concentration in the edible parts of crops and to satisfy the daily Se intake. Moreover, Se at low concentrations has been used to mitigate the toxicity of many metal(loid)s. In this review, we present an overview of the latest knowledge and practices with regards to the utilization of Se to reduce the uptake/toxicity of metal(loid)s in plants. We have focused on the following issues: 1) the current status of understanding the mechanisms of detoxification and uptake restriction of metal(loid)s regulated by Se; 2) the optimal dose and speciation of Se, and stage of plant growth that is optimal for application; 3) the differences in the efficiency of different application methods of Se including seed priming, base application, and foliar spray of Se fertilizers; 4) the possibility of using Se along with other methods to reduce multiple metal(loid) accumulation in crops; and 5) potential risks when Se is used to reduce metal(loid) accumulation in crops.